All posts by a_jones

Seratonin Syndrome

ABSTRACT
Serotonin syndrome is an iatrogenic disorder induced by pharmacologic treatment with serotonergic agents that increases serotonin activity. In addition, there is a wide variety of clinical disorders associated with serotonin excess. The frequent concurrent use of serotonergic and neuroleptic drugs and similarities between serotonin syndrome and neuroleptic malignant syndrome can present the clinician with a diagnostic challenge. In this article, we review the pathophysiology, diagnosis, and treatment of serotonin syndrome as well as other serotonergic disorders.

Full article – https://academic.oup.com/painmedicine/article/4/1/63/1816666

Apology from PAST.Wales

With sadness, once again there was an attempt to hack our website yesterday. The intruder(s) attempted to plant malware and redirect the site to a spurious website. Thankfully it was caught early, (within the hour), and repaired before any damage was caused.

The identity of the intruder(s) is not known as yet however we are making further investigations in partnership with our hosts.

We wish to reassure that no data was stolen or modified and no client or personal data was breached.

However, if you were affected please email@past.wales with your experience, and we truly apologise for any inconvenience caused – and have since retightened security once more.

Anxiety and Medication

“It’s a vicious circle,” Dr. Miller says. “So the person starts taking the medication because they’re anxious. The medication, however, affects the brain by actually making you more anxious. So pretty soon, people feel like without this medication, ‘I’m anxious all the time.’ When in fact, what they’re experiencing is just withdrawal from the medication.”

Duh! And we as patients don’t know??

Sad. Patient experience is disregarded.

Full article

https://news4sanantonio.com/news/local/the-pills-doctors-are-calling-the-next-drug-crisis

Avoiding Withdrawal Syndrome for SSRIs Requires Months, Not Weeks, and a More Gradual Curve, Paper Concludes

New research questions conventional practices regarding rapid withdrawal from selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, which are sometimes prescribed for migraine, peripheral neuropathy, and other neurologic disorders. Neurologists who prescribe these drugs said the study recommendations fit with their own clinical experience.

Tapering patients off selective serotonin reuptake inhibitors (SSRIs) should be done much more slowly and gradually than currently recommended, over a period of months rather than weeks, in order to avoid withdrawal syndrome, a team of researchers suggested in a paper published online March 5 in Lancet Psychiatry.

Although serotonin and norepinephrine reuptake inhibitors (SNRIs) were not the subject of the paper, studies show they show the same hyperbolic dose-response pattern, said the paper’s first author, Mark Abie Horowitz, PhD, a neurobiologist who is currently a clinical research fellow at University College London and a psychiatry trainee at Prince of Wales Hospital in Sydney, Australia.

“The clinical data also show that withdrawal symptoms from SNRIs last much longer than the one to two weeks ascribed to them by standard texts, much more in the region of months,” Dr. Horowitz told Neurology Today. “Tapering protocols suggested for SSRIs in the paper also apply to SNRIs; they should occur over at least months, down to doses close to one-fortieth of therapeutic doses and titrated to individual tolerability.”

The study authors proposed what they call a “pharmacologically informed method for tapering SSRI treatment.”

For instance, reducing doses of citalopram in steady 5 mg decrements resulted in serotonin transporter inhibition hyperbolically rising from 3 percent when the dose was cut from 20 mg to 15 mg, to 6 percent when the dose was cut from 15 mg to 10 mg, to 13 percent when the dose was cut to 5 mg, and to 58 percent when cut to zero.

“These large reductions in inhibition could account for the paucity of success of previous tapering regimens, and particularly for the difficulties with withdrawal symptoms that patients have towards the end of their taper, at low doses,” the study authors concluded.

Rather than taper by fixed amounts, the study authors recommended that clinicians taper the dose by following a hyperbolic slope. In the case of citalopram, for instance, the dose would be dropped from 20 mg, to 9.1 mg, to 5.4 mg, 3.4 mg, 2.3 mg, 1.5 mg, and then to 0.8 mg, 0.4 mg, and finally to zero.

Neurologists who treat migraine, diabetic neuropathy, and other disorders for which SSRIs and SNRIs are sometimes prescribed said the recommendations fit with their own clinical experience.

“I have seen the withdrawal effect; it can go on for months,” said Richard B. Lipton, MD, FAAN, the Edwin S. Lowe Professor and vice chair of neurology at Albert Einstein College of Medicine, where he is also director of the Montefiore Headache Center. “I definitely agree with the authors of this paper on the need for more gradual tapering in some patients. I’ve certainly had certain patients buy pill cutters to cut an already low dose of an SSRI into quarters and take them daily, then take them every other day, to try to make the taper more comfortable.”

Dr. Lipton said he also agreed with the authors of the paper that current guidelines on tapering SSRIs should be reconsidered, and that randomized, controlled trials would be useful to more rigorously test the effects of a slower, more gradual tapering protocol.

Full article –

https://journals.lww.com/neurotodayonline/pages/articleviewer.aspx?year=2019&issue=04180&article=00004&type=Fulltext

UK’s top paramedic Malcolm Woollard died of prescription drug overdose

Britain’s top paramedic, 57, was found dead in bed by neighbour after taking accidental overdose of morphine prescribed for his chronic back pain

Britain’s top paramedic died after overdosing on the 19 drugs he took for back pain each day, an inquest heard.

Professor Malcolm Woollard, 57, was found lying naked in his bed in Llangattock, near Abergavenny, South Wales in July last year.

He was discovered after a neighbour became concerned with mail piling up outside his house – but could have been dead for a week before he was found.

Pontypridd Coroner’s Court heard he had chronic back pain and was regularly admitted to hospital for taking too much morphine.

He was the first paramedic in the UK to be awarded the title of Professor and was Chairman of the British Paramedics Association

More….

https://www.dailymail.co.uk/news/article-6573327/Chairman-Paramedics-Association-Malcolm-Woollard-overdosed-prescription-drugs-inquest-hears.html

The new drug that addicts are turning to because heroin isn’t enough

It’s designed to treat epilepsy but heroin addicts are now using the legal drug Pregabalin to get their fix

An epilepsy drug known as ‘the new Diazepam’ is being linked to an increasing number of deaths among drug users in Wales.

The Home Office announced in October that Pregabalin – which is used to treat epilepsy, anxiety, and nerve pain, among other conditions – will become a Class C drug from next April due to the rising number of deaths linked to the drug.

In Wales Pregabalin – which is marketed under names including Lyrica and others – was first mentioned in a death certificate in 2013, when one death was recorded. Since then the number has grown from two in 2014 to nine in 2017.

https://www.walesonline.co.uk/news/wales-news/new-drug-addicts-turning-because-15433365

Mental Health

e-Petition: Add Mental Health Education to the mandatory teaching curriculum for all schools in Wales

open quote / dyfyniad agored

When working for Mental – The Podcast to Destigmatise Mental Health, I am continually concerned by the lack of education in schools around mental health. With 1 in 4 of us experiencing mental illness every year according to the charity Mind, this seems to be a real and significant gap in our education system.

KEY STATISTICS:

Over half of all mental ill health starts before the age of 14, and 75% of this has developed by the age of 18;

A 2015 survey found that 13% of adults (16 & older) living in Wales were reported to have received treatment for a mental health problem, an increase from 12% reported in 2014;

The overall cost of mental health problems in Wales is an estimated £7.2 billion a year.

The statistics are shocking, yet whilst there is a whole subject in the Welsh curriculum about our physical health in the form of PE, our young people are left without knowledge of even the most common mental illnesses.
Not only does this leave them unprepared & vulnerable when it comes to looking out for their own mental health, but also sets the standard that Mental Health is not discussed. This plants a seed of stigma that many carry for their whole lives.

We are keen to hear back from those in power on a more extensive plan to better the lives of Wales’s young people.

CAMPAIGNING FOR:

Mental Health education becoming mandatory teaching for all schools in Wales without the addition of any exams/homework on this subject.
Every child in Wales having the ability to access a qualified counsellor through their school.
Every school in Wales offering Mental Health training for its staff.

Please join our petition to help bring us one step closer to making these requests a reality for Welsh children, thus safeguarding the health of generations to come.

Thank you for reading, Annie Harris

Learn more about this petition & the team behind it at mentalpodcast.co.uk/petition

1. Source: Murphy M and Fonagy P (2012). Mental health problems in children and young people. In: Annual Report of the Chief Medical Officer 2012. London: Department of Health.

2. and 3. Source: Mental Health Foundation. Mental Health in Wales, Fundamental Facts 2016 (https://www.mentalhealth.org.uk/sites/default/files/FF16%20Wales.pdf)

Please see https://www.change.org/p/get-mental-health-education-on-the-school-curriculum-mentalpetition-join-me-and-over-100-000-others for the national interest in this petition. We handed in the petition to 10 Downing Street on 3rd October 2018.

Sign here

https://www.assembly.wales/en/gethome/e-petitions/Pages/petitiondetail.aspx?PetitionID=1446

EXPERIENCES OF DEPENDENCE TO PRESCRIBED PAIN MEDICATION

EXPERIENCES OF DEPENDENCE TO PRESCRIBED PAIN MEDICATION

Hello, my name is Louise and I am a student from the University of Surrey. I am looking for UK based participants over 18 years of age to take part in my study.

I am looking to talk to people about their experiences of dependence on prescribed medication for pain. Please note this study is confidential and anonymous.

If you would like to be involved or have any questions email me at ln00214@surrey.ac.uk

This study has been approved by the University of Surrey’s Faculty of Health and Medical Sciences’ Ethics Committee.

The Top 20 Medications That Cause Memory Loss

Here is a list of medications known to have memory loss as a side effect:

  • for Parkinson’s — scopolamine, atropine, glycopyrrolate
  • for epilepsy — phenytoin or Dilantin
  • painkillers — heroin, morphine, codeine
  • sleeping pills — Ambien, Lunesta, Sonata
  • benzodiazepines — Valium, Xanax, Ativan, Dalmane
  • quinidine
  • naproxen
  • steroids
  • antibiotics (quinolones)
  • antihistamines
  • interferons
  • high blood pressure drugs
  • insulin
  • beta blockers (especially those used for glaucoma)
  • methyldopa
  • antipsychotics — Haldol, Mellaril
  • tricyclic antidepressants
  • lithium
  • barbiturates — Amytal, Nembutal, Seconal, phenobarbital
  • chemotherapy drugs

This list was assembled by Richard C. Mohs, Ph.D., former vice chairman of the Department of Psychiatry at the Mount Sinai School of Medicine.

The Top 3 Types of Drugs That Cause Memory Loss

If you are taking any prescription medication, the odds are that it falls into one of these three categories of drugs known to cause memory loss and other cognitive problems:

The “Anti” Drugs

If you take a drug that starts with “anti,” such as antihistamines, antidepressants, antipsychotics, antibiotics, antispasmodics, or antihypertensives, it’s likely that it will affect your acetylcholine levels.

Acetylcholine is the primary neurotransmitter involved with memory and learning. Low acetycholine can lead to symptoms that resemble dementia including mental confusion, delirium, blurred vision, memory loss, and hallucinations.

Sleeping Pills

Prescription sleeping pills are notorious for causing memory loss.

The popular drug Ambien has been coined by some as “the amnesia drug.” Some users experience night terrors, sleep walking, sleep driving, and hallucinations.

Prescription sleeping pills have been found to put you in a state similar to being passed out drunk or in a coma while bypassing the restorative sleep your brain needs. There are much better ways to get to sleep!

https://realfarmacy.com/beware-20-medications-cause-memory-loss/